LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: European
Study Design: The chromosomal region 11p.15.5 was investigated in 1321 centenarians and 1140 younger subjects from European samples
Conclusions: No significant results were observed for genes previously associated with longevity: TH, IGF2, INS and HRAS1

HGNC symbol: IGF2
Aliases: GRDF; IGF-II; PP9974; C11orf43
Common name: insulin like growth factor 2
Description: This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Other longevity studies of this gene: 6
OMIM: 147470
Ensembl: ENSG00000167244
UniProt/Swiss-Prot: E3UN46_HUMAN
Entrez Gene: 3481
UniGene: 272259
HapMap: View on HapMap

GenAge human genes

Lescai et al. (2009)