LongevityMap variant

Entry Details

Longevity Association: Significant
Population: Dutch
Study Design: 1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
Conclusions: As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing

HGNC symbol: SGK1
Aliases: SGK
Common name: serum/glucocorticoid regulated kinase 1
Description: This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
Other longevity studies of this gene: 1
OMIM: 602958
Ensembl: ENSG00000118515
UniProt/Swiss-Prot: B7Z325_HUMAN
Entrez Gene: 6446
UniGene: 510078
HapMap: View on HapMap

GenAge model organism genes

GenAge microarray genes

GenDR gene manipulations

CellAge

Passtoors et al. (2013)