GenAge entry for FOXO4 (Homo sapiens)
Gene name (HAGRID: 183)
- HGNC symbol
- FOXO4
- Aliases
- AFX1; MLLT7
- Common name
- forkhead box O4
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
- Description
A member of the forkhead family, FOXO4 plays a role in development [802] and in insulin (INS) signalling. In roundworms, a homologue of FOXO4, daf-16, has been associated with ageing [628], and overexpression of another homologue, dFOXO, in adult fat body of fruit flies increased longevity in females [1238]. In mice targeting the interaction between FOXO4 and TP53 in senescent cells has been found to trigger apoptosis, demonstrating FOXO4 as a pivot in senescent cell viability. This targeted apoptosis restored fitness, fur density and renal function [4506]. FOXO4's role in human ageing has not yet been determined.
Cytogenetic information
- Cytogenetic band
- Xq13.1
- Location
- 71,096,149 bp to 71,103,534 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006355; regulation of transcription, DNA-templated
GO:0006366; transcription from RNA polymerase II promoter
GO:0007050; cell cycle arrest
GO:0007095; mitotic G2 DNA damage checkpoint
GO:0007517; muscle organ development
GO:0007568; aging
GO:0008285; negative regulation of cell proliferation
GO:0008286; insulin receptor signaling pathway
GO:0014911; positive regulation of smooth muscle cell migration
GO:0016525; negative regulation of angiogenesis
GO:0031667; response to nutrient levels
And 7 more GO terms Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
Function: GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008013; beta-catenin binding
GO:0008134; transcription factor binding
GO:0019899; enzyme binding
GO:0042802; identical protein binding
GO:0043565; sequence-specific DNA binding
GO:1990841; promoter-specific chromatin binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- AKT1, PIN1, CREBBP, FEN1, FOXO1, SIRT1, MDM2, ESR1, CTNNB1
- STRING interaction network
Retrieve sequences for FOXO4
Homologs in model organisms
- Caenorhabditis elegans
- daf-16
- Danio rerio
- foxo4
- Drosophila melanogaster
- foxo
- Mus musculus
- Foxo4
- Rattus norvegicus
- Foxo4
- Saccharomyces cerevisiae
- HCM1
- Schizosaccharomyces pombe
- sep1
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- LongevityMap
- This gene is present as FOXO4
- CellAge
- This gene is present as FOXO4
Selected references
External links
- EPD
- ORF Accession
- NM_005938
- CDS Accession
- NP_005929
- OMIM
- 300033
- HPRD
- 02070
- Ensembl
- FOXO4
- UniProt/Swiss-Prot
- FOXO4_HUMAN
- GeneCards
- FOXO4
- Entrez Gene
- 4303
- GenAtlas
- FOXO4
- Internet
- Search Google