GenAge entry for UCP1 (Homo sapiens)
Gene name (HAGRID: 258)
- HGNC symbol
- UCP1
- Aliases
- SLC25A7; UCP
- Common name
- uncoupling protein 1 (mitochondrial, proton carrier)
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
Mitochondrial uncoupling proteins create proton leaks across the inner mitochondrial membrane to uncouple oxidative phosphorylation from ATP synthesis resulting in energy being dissipated as heat. Mice with skeletal muscle-specific UCP1 expression had increased median survival, decreased adiposity, increased temperature and metabolic rate. The same genetic manipulation in APOE null mice decreased diet-induced atherosclerosis and in agouti yellow mice, a model of obesity, diabetes and hypertension were reversed [1850].
Cytogenetic information
- Cytogenetic band
- 4q28-q31
- Location
- 140,559,896 bp to 140,568,805 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0002024; diet induced thermogenesis
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0009266; response to temperature stimulus
GO:0015992; proton transport
GO:0031667; response to nutrient levels
GO:0032870; cellular response to hormone stimulus
GO:0034614; cellular response to reactive oxygen species
GO:0050873; brown fat cell differentiation
GO:0071398; cellular response to fatty acid
GO:1903426; regulation of reactive oxygen species biosynthetic process
GO:1990542; mitochondrial transmembrane transport
And 2 more GO terms Cellular component: GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0016021; integral component of membrane
Function: GO:0017077; oxidative phosphorylation uncoupler activity
GO:0022857; transmembrane transporter activity
GO:0032555; purine ribonucleotide binding
GO:0036041; long-chain fatty acid binding
GO:1901612; cardiolipin binding
Protein interactions and network
No interactions in records.
Retrieve sequences for UCP1
Homologs in model organisms
- Danio rerio
- ucp1
- Mus musculus
- Ucp1
- Rattus norvegicus
- Ucp1
- Rattus norvegicus
- LOC100909612
- Saccharomyces cerevisiae
- DIC1
In other databases
- LongevityMap
- This gene is present as UCP1
Selected references
External links
- EPD
- ORF Accession
- NM_021833
- CDS Accession
- NP_068605
- OMIM
- 113730
- HPRD
- 00221
- Ensembl
- UCP1
- UniProt/Swiss-Prot
- UCP1_HUMAN
- GeneCards
- UCP1
- Entrez Gene
- 7350
- GenAtlas
- UCP1
- Internet
- Search Google