GenAge entry for TXN (Homo sapiens)
Gene name (HAGRID: 16)
- HGNC symbol
- TXN
- Aliases
- TRX
- Common name
- thioredoxin
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
- Description
TXN plays a role in regulating the cellular redox status. Some evidence also indicates TXN is a growth-suppressor [242]. TXN overexpression in the neurons of flies extended the mean lifespan by 15% [1931]. Its overexpression in mice increases lifespan, but it is not known whether the ageing process is affected [19]. Another study found no overall effects on lifespan of overexpression in mice, although it could be beneficial in the earlier part of life [1959]. As such, its role in human ageing remains unclear.
Cytogenetic information
- Cytogenetic band
- 9q31
- Location
- 110,243,812 bp to 110,256,640 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000302; response to reactive oxygen species
GO:0006351; transcription, DNA-templated
GO:0006662; glycerol ether metabolic process
GO:0006928; movement of cell or subcellular component
GO:0007165; signal transduction
GO:0007267; cell-cell signaling
GO:0008283; cell proliferation
GO:0009314; response to radiation
GO:0015949; nucleobase-containing small molecule interconversion
GO:0030091; protein repair
And 11 more GO terms Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0070062; extracellular exosome
Function: GO:0004791; thioredoxin-disulfide reductase activity
GO:0005515; protein binding
GO:0015035; protein disulfide oxidoreductase activity
GO:0015037; peptide disulfide oxidoreductase activity
GO:0016671; oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
GO:0044822; poly(A) RNA binding
GO:0047134; protein-disulfide reductase activity
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, MYC, EGFR, PTEN, NR3C1, NFKB1, EEF2, SOD1, PRDX1, GPX1, MAP3K5, APEX1, RAE1, MLH1, CDKN1A
- STRING interaction network
Retrieve sequences for TXN
Homologs in model organisms
- Danio rerio
- txn
- Danio rerio
- zgc:56493
- Mus musculus
- Txn1
- Rattus norvegicus
- Txn1
- Saccharomyces cerevisiae
- TRX2
- Saccharomyces cerevisiae
- TRX1
- Schizosaccharomyces pombe
- trx1
In other databases
- GenAge model organism genes
- CellAge
- This gene is present as TXN