GenAge entry for SERPINE1 (Homo sapiens)

Gene name (HAGRID: 301)

HGNC symbol: SERPINE1
Aliases: PAI; PLANH1; PAI1
Common name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: PAI-1 (SERPINE1) is a serine protease inhibitor, which is elevated in Klotho (KL)-deficient mice. Klotho-deficient mice exhibit an accelerated aging-like phenotype including reduced lifespan, arteriosclerosis, and emphysema. PAI-1 deficiency retards the development of senescence and protects organ structure and function while prolonging the lifespan of the Klotho mutant mice [3484].

Cytogenetic information

Cytogenetic band: 7q22.1
Location: 101,127,089 bp to 101,139,266 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001300; chronological cell aging
GO:0001525; angiogenesis
GO:0002576; platelet degranulation
GO:0007623; circadian rhythm
GO:0010469; regulation of receptor activity
GO:0010757; negative regulation of plasminogen activation
GO:0010951; negative regulation of endopeptidase activity
GO:0014912; negative regulation of smooth muscle cell migration
GO:0030194; positive regulation of blood coagulation
GO:0030195; negative regulation of blood coagulation
GO:0030198; extracellular matrix organization

And 19 more GO terms

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005886; plasma membrane
GO:0031012; extracellular matrix
GO:0031093; platelet alpha granule lumen
GO:0070062; extracellular exosome

Function:

GO:0002020; protease binding
GO:0004867; serine-type endopeptidase inhibitor activity
GO:0005102; receptor binding
GO:0005515; protein binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: PLAU, SERPINE1
STRING interaction network

Retrieve sequences for SERPINE1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: srp-3
Caenorhabditis elegans: srp-2
Caenorhabditis elegans: srp-1
Caenorhabditis elegans: srp-7
Caenorhabditis elegans: srp-6
Caenorhabditis elegans: srp-8
Danio rerio: serpine1
Drosophila melanogaster: Spn38F
Drosophila melanogaster: Spn28F
Drosophila melanogaster: Spn42Dd
Drosophila melanogaster: Spn42Da
Drosophila melanogaster: Spn28Db
Drosophila melanogaster: Spn55B
Drosophila melanogaster: Spn42Db
Drosophila melanogaster: Spn28Da
Drosophila melanogaster: Spn28B
Drosophila melanogaster: Spn42Dc
Drosophila melanogaster: Spn42De
Drosophila melanogaster: nec
Drosophila melanogaster: Spn43Aa
Drosophila melanogaster: Spn43Ab
Drosophila melanogaster: Spn47C
Mus musculus: Serpine1
Rattus norvegicus: Serpine1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Serpine1

GenAge microarray genes

This gene is present as SERPINE1

LongevityMap

This gene is present as SERPINE1

CellAge

This gene is present as SERPINE1