GenAge entry for PTK2B (Homo sapiens)
Gene name (HAGRID: 165)
- HGNC symbol
- PTK2B
- Aliases
- CAKB; PYK2; RAFTK; PTK; CADTK; FAK2
- Common name
- protein tyrosine kinase 2 beta
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
Involved in stress response and signal transduction, PTK2B is an important player in a variety of processes including the regulation of ion channels by calcium and MAPK signalling [769]. PTK2B is a focal adhesion kinase (FAK), which could be involved in cellular senescence and apoptosis [1716]. Its role, if any, in human ageing is unknown, but PTK2B could potentially be involved in downstream signalling cascades related to ageing.
Cytogenetic information
- Cytogenetic band
- 8p21.1
- Location
- 27,311,482 bp to 27,459,391 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000165; MAPK cascade
GO:0001525; angiogenesis
GO:0001556; oocyte maturation
GO:0001666; response to hypoxia
GO:0001954; positive regulation of cell-matrix adhesion
GO:0002040; sprouting angiogenesis
GO:0002250; adaptive immune response
GO:0002315; marginal zone B cell differentiation
GO:0006461; protein complex assembly
GO:0006468; protein phosphorylation
GO:0006915; apoptotic process
And 81 more GO terms Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005856; cytoskeleton
GO:0005925; focal adhesion
GO:0005938; cell cortex
GO:0014069; postsynaptic density
GO:0017146; NMDA selective glutamate receptor complex
GO:0030027; lamellipodium
GO:0030424; axon
And 9 more GO terms Function: GO:0004683; calmodulin-dependent protein kinase activity
GO:0004713; protein tyrosine kinase activity
GO:0004715; non-membrane spanning protein tyrosine kinase activity
GO:0004871; signal transducer activity
GO:0004972; NMDA glutamate receptor activity
GO:0005102; receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0032403; protein complex binding
GO:0043423; 3-phosphoinositide-dependent protein kinase binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- PTPN11, IL7R, EGFR, ERBB2, PRKCD, PTEN, HSP90AA1, GRB2, PTK2B, MAPT, JAK2, SOCS2
- STRING interaction network
Retrieve sequences for PTK2B
Homologs in model organisms
- Caenorhabditis elegans
- kin-32
- Danio rerio
- ptk2ba
- Danio rerio
- ptk2bb
- Mus musculus
- Ptk2b
- Rattus norvegicus
- Ptk2b
Selected references
External links
- EPD
- ORF Accession
- NM_173174
- CDS Accession
- NP_775266
- OMIM
- 601212
- HPRD
- 03131
- Ensembl
- PTK2B
- UniProt/Swiss-Prot
- FAK2_HUMAN
- GeneCards
- PTK2B
- Entrez Gene
- 2185
- GenAtlas
- PTK2B
- Internet
- Search Google