GenAge entry for PRKCA (Homo sapiens)
Gene name (HAGRID: 99)
- HGNC symbol
- PRKCA
- Aliases
- PKCA
- Common name
- protein kinase C, alpha
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
PRKCA is a phorbol ester receptor involved in signal transduction. It appears to interact with many proteins, including some that have been related to ageing, such as LMNA and INSR. In the medfly, PRKCA levels are age-dependent [535]. PRKCA has not been directly related to human ageing.
Cytogenetic information
- Cytogenetic band
- 17q22-q23.
- Location
- 66,302,808 bp to 66,810,744 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0001525; angiogenesis
GO:0001938; positive regulation of endothelial cell proliferation
GO:0002159; desmosome assembly
GO:0006468; protein phosphorylation
GO:0007077; mitotic nuclear envelope disassembly
GO:0007155; cell adhesion
GO:0007190; activation of adenylate cyclase activity
GO:0007194; negative regulation of adenylate cyclase activity
GO:0010595; positive regulation of endothelial cell migration
GO:0010613; positive regulation of cardiac muscle hypertrophy
GO:0018105; peptidyl-serine phosphorylation
And 19 more GO terms Cellular component: GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005783; endoplasmic reticulum
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0031966; mitochondrial membrane
GO:0048471; perinuclear region of cytoplasm
GO:0070062; extracellular exosome
Function: GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0004697; protein kinase C activity
GO:0004698; calcium-dependent protein kinase C activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008270; zinc ion binding
GO:0019899; enzyme binding
GO:0035403; histone kinase activity (H3-T6 specific)
Protein interactions and network
- Protein-protein interacting partners in GenAge
- LMNA, EGFR, PLCG2, HSP90AA1, TOP2A, EP300, GSK3B, PRKCA, FAS, YWHAZ, LMNB1, NFKBIA, MTOR, CTNNB1, CDKN2A, PPARG, NFE2L2, GSK3A, IKBKB, RICTOR
- STRING interaction network
Retrieve sequences for PRKCA
Homologs in model organisms
- Caenorhabditis elegans
- pkc-2
- Danio rerio
- prkca
- Danio rerio
- PRKCA (1 of many)
- Drosophila melanogaster
- Pkc53E
- Drosophila melanogaster
- inaC
- Mus musculus
- Prkca
- Rattus norvegicus
- Prkca
- Saccharomyces cerevisiae
- PKC1
In other databases
- LongevityMap
- This gene is present as PRKCA
Selected references
External links
- EPD
- ORF Accession
- NM_002737
- CDS Accession
- NP_002728
- OMIM
- 176960
- HPRD
- 01498
- Ensembl
- PRKCA
- UniProt/Swiss-Prot
- KPCA_HUMAN
- GeneCards
- PRKCA
- Entrez Gene
- 5578
- GenAtlas
- PRKCA
- Internet
- Search Google