GenAge entry for POLG (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 72)
- HGNC symbol
- POLG
- Aliases
- POLG1; POLGA
- Common name
- polymerase (DNA directed), gamma
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
POLG is involved in mitochondrial DNA replication and repair [1060]. Mice with a proof-reading-deficient version of POLG display signs of premature ageing starting at about 25 weeks of age [1059]. Although the exact molecular and cellular events responsible for such phenotype are not clear, they could involve the accumulation of mitochondrial DNA mutations and an increased apoptosis [1466]. In humans, mutations in POLG have been associated with CNS diseases [1055]. Further studies are necessary to determine whether POLG plays a role in human ageing.
Cytogenetic information
- Cytogenetic band
- 15q25
- Location
- 89,316,305 bp to 89,334,795 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0006259; DNA metabolic process
GO:0006261; DNA-dependent DNA replication
GO:0006264; mitochondrial DNA replication
GO:0006287; base-excision repair, gap-filling
GO:0007568; aging
GO:0009416; response to light stimulus
GO:0010332; response to gamma radiation
GO:0055093; response to hyperoxia
GO:0071333; cellular response to glucose stimulus
GO:0071897; DNA biosynthetic process
GO:0090305; nucleic acid phosphodiester bond hydrolysis
And 1 more GO terms Cellular component: GO:0005739; mitochondrion
GO:0005760; gamma DNA polymerase complex
GO:0042645; mitochondrial nucleoid
GO:0043195; terminal bouton
GO:0043234; protein complex
GO:0070062; extracellular exosome
Function: GO:0002020; protease binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003887; DNA-directed DNA polymerase activity
GO:0005515; protein binding
GO:0008408; 3'-5' exonuclease activity
Protein interactions and network
No interactions in records.
Retrieve sequences for POLG
Homologs in model organisms
- Caenorhabditis elegans
- polg-1
- Danio rerio
- polg
- Drosophila melanogaster
- tam
- Mus musculus
- Polg
- Rattus norvegicus
- Polg
- Saccharomyces cerevisiae
- MIP1
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Polg
- LongevityMap
- This gene is present as POLG
Selected references
External links
- EPD
- ORF Accession
- NM_002693
- CDS Accession
- NP_002684
- OMIM
- 174763
- HPRD
- 01438
- Ensembl
- POLG
- UniProt/Swiss-Prot
- DPOG1_HUMAN
- GeneCards
- POLG
- Entrez Gene
- 5428
- GenAtlas
- POLG
- Internet
- Search Google