GenAge entry for POLD1 (Homo sapiens)
Gene name (HAGRID: 118)
- HGNC symbol
- POLD1
- Aliases
- CDC2; POLD
- Common name
- polymerase (DNA directed), delta 1, catalytic subunit
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
POLD1 is mostly involved in DNA synthesis, and probably it also functions in DNA repair [920]. Mice with a proofreading-deficient version of POLD1 have a higher cancer incidence [917]. POLD1 has also been associated with WRN [922]. There is no direct evidence linking POLD1 to human ageing, but it should be considered a suspect gene.
Cytogenetic information
- Cytogenetic band
- 19q13.3
- Location
- 50,384,323 bp to 50,418,018 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000722; telomere maintenance via recombination
GO:0000723; telomere maintenance
GO:0000731; DNA synthesis involved in DNA repair
GO:0006260; DNA replication
GO:0006271; DNA strand elongation involved in DNA replication
GO:0006281; DNA repair
GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006287; base-excision repair, gap-filling
GO:0006296; nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006297; nucleotide-excision repair, DNA gap filling
GO:0006298; mismatch repair
And 8 more GO terms Cellular component: GO:0000109; nucleotide-excision repair complex
GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0016020; membrane
GO:0016235; aggresome
GO:0043625; delta DNA polymerase complex
Function: GO:0000166; nucleotide binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003684; damaged DNA binding
GO:0003887; DNA-directed DNA polymerase activity
GO:0005515; protein binding
GO:0008296; 3'-5'-exodeoxyribonuclease activity
GO:0019899; enzyme binding
GO:0046872; metal ion binding
GO:0051539; 4 iron, 4 sulfur cluster binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- MYC, RPA1, ERCC6, PCNA, TERF2, ATR, SPRTN
- STRING interaction network
Retrieve sequences for POLD1
Homologs in model organisms
- Caenorhabditis elegans
- F10C2.4
- Danio rerio
- pold1
- Drosophila melanogaster
- DNApol-delta
- Mus musculus
- Pold1
- Rattus norvegicus
- Pold1
- Saccharomyces cerevisiae
- POL3
- Schizosaccharomyces pombe
- pol3
In other databases
Selected references
External links
- EPD
- ORF Accession
- NM_002691
- CDS Accession
- NP_002682
- OMIM
- 174761
- HPRD
- 08882
- Ensembl
- POLD1
- UniProt/Swiss-Prot
- DPOD1_HUMAN
- GeneCards
- POLD1
- Entrez Gene
- 5424
- GenAtlas
- POLD1
- Internet
- Search Google