GenAge entry for PMCH (Homo sapiens)

Gene name (HAGRID: 242)

HGNC symbol
PMCH 
Aliases
MCH 
Common name
pro-melanin-concentrating hormone 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

PMCH is a cyclic neuropeptide that appears to be involved in a number of neuronal functions such as food intake [1599]. PMCH overexpression leads to obesity and insulin (INS) resistance [1598]. In contrast, PMCH null mice are resistant to ageing-associated increases in body weight and INS resistance [1601]. While it is dubious that PMCH is a major factor in ageing, it could play a role in some age-related changes.

Cytogenetic information

Cytogenetic band
12q23.2
Location
102,196,459 bp to 102,197,845 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0007218; neuropeptide signaling pathway
GO:0007268; chemical synaptic transmission
GO:0007275; multicellular organism development
GO:0007283; spermatogenesis
GO:0007631; feeding behavior
GO:0030154; cell differentiation
Cellular component: GO:0005576; extracellular region
GO:0005634; nucleus
Function: GO:0030354; melanin-concentrating hormone activity
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for PMCH

ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Pmch
Rattus norvegicus
Pmch

Selected references

External links

EPD
ORF Accession
NM_002674
CDS Accession
NP_002665
OMIM
176795
HPRD
01459
Ensembl
PMCH
UniProt/Swiss-Prot
MCH_HUMAN
GeneCards
PMCH
Entrez Gene
5367
GenAtlas
PMCH
Internet
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