GenAge entry for NRG1 (Homo sapiens)
Gene name (HAGRID: 24)
- HGNC symbol
- NRG1
- Aliases
- HRG; NDF; GGF; HGL; NRG1-IT2
- Common name
- neuregulin 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
The NRG1 gene encodes multiple transcripts that appear to play a role in neuronal development, differentiation, and apoptosis [272]. It may be involved in neurodegenerative pathologies [1297], but it is unknown whether it plays a role in human ageing.
Cytogenetic information
- Cytogenetic band
- 8p12
- Location
- 32,646,732 bp to 32,743,252 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000165; MAPK cascade
GO:0000187; activation of MAPK activity
GO:0000902; cell morphogenesis
GO:0001964; startle response
GO:0003161; cardiac conduction system development
GO:0003222; ventricular trabecula myocardium morphogenesis
GO:0007154; cell communication
GO:0007171; activation of transmembrane receptor protein tyrosine kinase activity
GO:0007399; nervous system development
GO:0007416; synapse assembly
GO:0007422; peripheral nervous system development
And 45 more GO terms Cellular component: GO:0005576; extracellular region
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005887; integral component of plasma membrane
GO:0009897; external side of plasma membrane
GO:0016020; membrane
GO:0030425; dendrite
GO:0030673; axolemma
GO:0031594; neuromuscular junction
GO:0044297; cell body
Function: GO:0003712; transcription cofactor activity
GO:0004713; protein tyrosine kinase activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005125; cytokine activity
GO:0005176; ErbB-2 class receptor binding
GO:0005178; integrin binding
GO:0008083; growth factor activity
GO:0030297; transmembrane receptor protein tyrosine kinase activator activity
GO:0030971; receptor tyrosine kinase binding
GO:0043125; ErbB-3 class receptor binding
GO:0045499; chemorepellent activity
And 2 more GO terms
Protein interactions and network
Retrieve sequences for NRG1
Homologs in model organisms
Selected references
External links
- EPD
- ORF Accession
- NM_013959
- CDS Accession
- NP_039253
- OMIM
- 142445
- HPRD
- 00802
- Ensembl
- NRG1
- UniProt/Swiss-Prot
- NRG1_HUMAN
- GeneCards
- NRG1
- Entrez Gene
- 3084
- GenAtlas
- NRG1
- Internet
- Search Google