GenAge entry for NOG (Homo sapiens)
Gene name (HAGRID: 229)
- HGNC symbol
- NOG
- Aliases
- SYNS1; SYM1
- Common name
- noggin
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
NOG appears to be involved in development, though its exact functions remain unclear. Mice without NOG die shortly after birth [1417]. Overexpression of NOG in mice resulted in severe osteoporosis [1412]. Mutations in the human NOG gene affect joint morphogenesis [1415]. NOG may be a factor in bone ageing, but its role in human ageing remains to be established.
Cytogenetic information
- Cytogenetic band
- 17q22
- Location
- 56,593,699 bp to 56,595,590 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001501; skeletal system development
GO:0001649; osteoblast differentiation
GO:0001701; in utero embryonic development
GO:0001706; endoderm formation
GO:0001707; mesoderm formation
GO:0001837; epithelial to mesenchymal transition
GO:0001839; neural plate morphogenesis
GO:0001843; neural tube closure
GO:0003149; membranous septum morphogenesis
GO:0003151; outflow tract morphogenesis
And 48 more GO terms Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
Function: GO:0005515; protein binding
GO:0019955; cytokine binding
GO:0042803; protein homodimerization activity
Protein interactions and network
Retrieve sequences for NOG
Homologs in model organisms
Selected references
External links
- EPD
- ORF Accession
- NM_005450
- CDS Accession
- NP_005441
- OMIM
- 602991
- HPRD
- 04291
- Ensembl
- NOG
- UniProt/Swiss-Prot
- NOGG_HUMAN
- GeneCards
- NOG
- Entrez Gene
- 9241
- GenAtlas
- NOG
- Internet
- Search Google