GenAge entry for NFKB2 (Homo sapiens)
Gene name (HAGRID: 20)
- HGNC symbol
- NFKB2
- Aliases
- LYT-10; p52; p105; NF-kB2
- Common name
- nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
NFKB2 is a component of the NF-kappa-B complex, involved in oxidative pathways and a myriad of other processes. Its role in ageing is unclear, even though NFKB2 appears to be related to age-related changes in inflammation and maybe in other age-related processes too [260]. In addition, age-relation changes in NF-kappa-B have been reported for numerous tissues [261].
Cytogenetic information
- Cytogenetic band
- 10q24
- Location
- 102,395,596 bp to 102,402,529 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0002268; follicular dendritic cell differentiation
GO:0002467; germinal center formation
GO:0006355; regulation of transcription, DNA-templated
GO:0006366; transcription from RNA polymerase II promoter
GO:0006954; inflammatory response
GO:0007249; I-kappaB kinase/NF-kappaB signaling
GO:0007568; aging
GO:0030198; extracellular matrix organization
GO:0032481; positive regulation of type I interferon production
GO:0032496; response to lipopolysaccharide
And 8 more GO terms Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0033257; Bcl3/NF-kappaB2 complex
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003713; transcription coactivator activity
GO:0005515; protein binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- NFKB2, STAT3, VCP, NR3C1, NFKB1, RELA, SP1, NFKBIA, EPS8
- STRING interaction network
Retrieve sequences for NFKB2
Homologs in model organisms
In other databases
- CellAge
- This gene is present as NFKB2
Selected references
External links
- EPD
- ORF Accession
- NM_002502
- CDS Accession
- NP_002493
- OMIM
- 164012
- HPRD
- 01239
- Ensembl
- NFKB2
- UniProt/Swiss-Prot
- NFKB2_HUMAN
- GeneCards
- NFKB2
- Entrez Gene
- 4791
- GenAtlas
- NFKB2
- Internet
- Search Google