GenAge entry for HESX1 (Homo sapiens)

Gene name (HAGRID: 184)

HGNC symbol: HESX1
Aliases: RPX; ANF
Common name: HESX homeobox 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: HESX1 is an important regulator of development and, particularly, of pituitary development. It may antagonize the transcriptional activities of PROP1 [1726]. Mice without HESX1 develop pituitary dysplasia. Mutations in the human HESX1 gene have been associated with septooptic dysplasia [803]. As a member of the hypothalamus-pituitary system, HESX1 might, in theory, be involved in ageing even if it has so far not been directly associated with human ageing.

Cytogenetic information

Cytogenetic band: 3p14.3
Location: 57,197,916 bp to 57,200,252 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006351; transcription, DNA-templated
GO:0007420; brain development
GO:0030916; otic vesicle formation
GO:0043584; nose development
GO:0045892; negative regulation of transcription, DNA-templated
GO:0048853; forebrain morphogenesis

Cellular component:

GO:0005634; nucleus

Function:

GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0005515; protein binding
GO:0008022; protein C-terminus binding
GO:0043565; sequence-specific DNA binding
GO:0047485; protein N-terminus binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: STAT3, NCOR1
STRING interaction network

Retrieve sequences for HESX1

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: hesx1
Mus musculus: Hesx1
Rattus norvegicus: Hesx1