GenAge entry for H2AFX (Homo sapiens)

Gene name (HAGRID: 212)

HGNC symbol
H2AFX 
Aliases
H2AX 
Common name
H2A histone family, member X 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Histones such as H2AFX are part of the nucleosome, which consists of DNA wrapped around histones. H2AFX has been involved in DNA repair together with, among others, NBN and TP53 [1004]. H2AFX-null mice were growth retarded and showed signs of genomic instability [1004]. Whether H2AFX plays a role in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band
11q23.3
Location
119,093,875 bp to 119,095,467 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000077; DNA damage checkpoint
GO:0000724; double-strand break repair via homologous recombination
GO:0006302; double-strand break repair
GO:0006303; double-strand break repair via nonhomologous end joining
GO:0006334; nucleosome assembly
GO:0006342; chromatin silencing
GO:0006974; cellular response to DNA damage stimulus
GO:0007283; spermatogenesis
GO:0010212; response to ionizing radiation
GO:0016032; viral process
GO:0021987; cerebral cortex development
And 5 more GO terms
Cellular component: GO:0000781; chromosome, telomeric region
GO:0000786; nucleosome
GO:0000790; nuclear chromatin
GO:0000794; condensed nuclear chromosome
GO:0001673; male germ cell nucleus
GO:0001741; XY body
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005657; replication fork
GO:0035861; site of double-strand break
GO:0070062; extracellular exosome
And 1 more GO terms
Function: GO:0003677; DNA binding
GO:0003684; damaged DNA binding
GO:0005515; protein binding
GO:0019899; enzyme binding
GO:0042393; histone binding
GO:0046982; protein heterodimerization activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, ATM, WRN, LMNA, NGFR, EGFR, NBN, PARP1, BRCA1, BLM, HSP90AA1, BRCA2, RAD51, STK11, PML, PRKDC, XRCC5, TERF2, XRCC6, FOXO3, SOD2, AIFM1, A2M, HSPA9, HSPA1A, MAPK8, YWHAZ, BMI1, EEF1A1, ATF2, ESR1, CLU, ATR, PPM1D, PAPPA, SIRT7, TP53BP1, TRAP1
STRING interaction network
Protein-Protein network diagram for H2AFX

Retrieve sequences for H2AFX

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
zgc:195633
Danio rerio
zgc:110434
Danio rerio
zgc:165551
Danio rerio
si:ch73-368j24.15
Danio rerio
zgc:101846
Danio rerio
zgc:165551
Danio rerio
h2afx
Danio rerio
si:ch1073-159d7.9
Danio rerio
zgc:110434
Danio rerio
zgc:195633
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33865
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33847
Drosophila melanogaster
His2A:CG33826
Drosophila melanogaster
His2A:CG33865
Mus musculus
H2afx
Rattus norvegicus
H2afx
Saccharomyces cerevisiae
HTA1

In other databases

LongevityMap
  • This gene is present as H2AFX
CellAge gene expression
  • This gene is present as H2AFX

Selected references

External links

EPD
ORF Accession
NM_002105
CDS Accession
NP_002096
OMIM
601772
HPRD
03465
Ensembl
H2AFX
UniProt/Swiss-Prot
H2AX_HUMAN
GeneCards
H2AFX
Entrez Gene
3014
GenAtlas
H2AFX
Internet
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