GenAge entry for GSTP1 (Homo sapiens)
Gene name (HAGRID: 157)
- HGNC symbol
- GSTP1
- Aliases
- GSTP; FAEES3; GST3
- Common name
- glutathione S-transferase pi 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
GSTP1 is part of the glutathione system involved in oxidative protection [44]. Overexpression of a homologue of GSTP1 in roundworms extended lifespan by about 22% [1548]. There is some evidence linking polymorphisms in the human GSTP1 gene to Parkinson's disease induced by pesticides [750], but GSTP1's role in human ageing remains unknown.
Cytogenetic information
- Cytogenetic band
- 11q13
- Location
- 67,583,595 bp to 67,586,653 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000302; response to reactive oxygen species
GO:0002674; negative regulation of acute inflammatory response
GO:0006469; negative regulation of protein kinase activity
GO:0006749; glutathione metabolic process
GO:0006805; xenobiotic metabolic process
GO:0007417; central nervous system development
GO:0009890; negative regulation of biosynthetic process
GO:0010804; negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0014003; oligodendrocyte development
GO:0031100; animal organ regeneration
GO:0032355; response to estradiol
And 33 more GO terms Cellular component: GO:0005615; extracellular space
GO:0005622; intracellular
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0031982; vesicle
GO:0070062; extracellular exosome
GO:0097057; TRAF2-GSTP1 complex
Function: GO:0004364; glutathione transferase activity
GO:0004602; glutathione peroxidase activity
GO:0005515; protein binding
GO:0008144; drug binding
GO:0008432; JUN kinase binding
GO:0019207; kinase regulator activity
GO:0035730; S-nitrosoglutathione binding
GO:0035731; dinitrosyl-iron complex binding
GO:0043295; glutathione binding
GO:0070026; nitric oxide binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- GSTP1, MAPK8, ATF2, MLH1, SIRT7
- STRING interaction network
Retrieve sequences for GSTP1
Homologs in model organisms
- Caenorhabditis elegans
- gst-23
- Caenorhabditis elegans
- gst-25
- Caenorhabditis elegans
- gst-41
- Caenorhabditis elegans
- gst-1
- Danio rerio
- gstp2
- Danio rerio
- gstp1
- Mus musculus
- Gstp1
- Mus musculus
- Gstp2
- Rattus norvegicus
- Gstp1