GenAge entry for GSTA4 (Homo sapiens)

Gene name (HAGRID: 156)

HGNC symbol: GSTA4
Aliases
Common name: glutathione S-transferase alpha 4

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: GSTA4 is part of the glutathione system involved in oxidative protection [44]. Expression of GSTA4 increases in the aged rat cerebral cortex [746]. There is no causal evidence, however, linking GSTA4 to ageing in humans or in model organisms.

Cytogenetic information

Cytogenetic band: 6p12.1
Location: 52,977,948 bp to 52,995,380 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006749; glutathione metabolic process
GO:0006805; xenobiotic metabolic process
GO:1901687; glutathione derivative biosynthetic process

Cellular component:

GO:0005829; cytosol

Function:

GO:0004364; glutathione transferase activity
GO:0005515; protein binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: GSTA4
STRING interaction network

Retrieve sequences for GSTA4

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: gst-13
Caenorhabditis elegans: gst-37
Caenorhabditis elegans: gst-26
Caenorhabditis elegans: gst-36
Caenorhabditis elegans: gst-9
Caenorhabditis elegans: gst-18
Caenorhabditis elegans: gst-5
Caenorhabditis elegans: gst-28
Caenorhabditis elegans: gst-29
Caenorhabditis elegans: gst-21
Caenorhabditis elegans: gst-35
Caenorhabditis elegans: gst-34
Caenorhabditis elegans: gst-30
Caenorhabditis elegans: gst-32
Caenorhabditis elegans: gst-39
Caenorhabditis elegans: gst-31
Caenorhabditis elegans: gst-6
Caenorhabditis elegans: gst-17
Caenorhabditis elegans: gst-27
Caenorhabditis elegans: gst-40
Caenorhabditis elegans: gst-3
Caenorhabditis elegans: gst-19
Caenorhabditis elegans: gst-16
Caenorhabditis elegans: gst-7
Caenorhabditis elegans: gst-20
Caenorhabditis elegans: gst-15
Caenorhabditis elegans: gst-2
Caenorhabditis elegans: gst-4
Caenorhabditis elegans: gst-12
Caenorhabditis elegans: gst-14
Caenorhabditis elegans: gst-38
Caenorhabditis elegans: gst-24
Caenorhabditis elegans: gst-8
Caenorhabditis elegans: gst-33
Caenorhabditis elegans: gst-22
Danio rerio: gsta.2
Danio rerio: gsta.1
Danio rerio: gsta.2

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as gst-5

LongevityMap

This gene is present as GSTA4