GenAge entry for GSS (Homo sapiens)
Gene name (HAGRID: 155)
- HGNC symbol
- GSS
- Aliases
- Common name
- glutathione synthetase
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
GSS is involved in redox regulation and oxidative defence. Mutations in the human GSS gene cause 5-oxoprolinuria [744]. There is no evidence directly linking GSS to ageing in humans or in model organisms.
Cytogenetic information
- Cytogenetic band
- 20q11.2
- Location
- 34,928,433 bp to 34,955,798 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0006520; cellular amino acid metabolic process
GO:0006750; glutathione biosynthetic process
GO:0006979; response to oxidative stress
GO:0007399; nervous system development
GO:0007568; aging
GO:0009410; response to xenobiotic stimulus
GO:0031667; response to nutrient levels
GO:0034612; response to tumor necrosis factor
GO:0043200; response to amino acid
GO:0046686; response to cadmium ion
Cellular component: GO:0005829; cytosol
GO:0070062; extracellular exosome
Function: GO:0000287; magnesium ion binding
GO:0004363; glutathione synthase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016594; glycine binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0043295; glutathione binding
Protein interactions and network
Retrieve sequences for GSS
Homologs in model organisms
- Caenorhabditis elegans
- gss-1
- Danio rerio
- gss
- Drosophila melanogaster
- CG32495
- Drosophila melanogaster
- GS
- Drosophila melanogaster
- GS
- Drosophila melanogaster
- CG32495
- Mus musculus
- Gss
- Rattus norvegicus
- Gss
- Saccharomyces cerevisiae
- GSH2
- Schizosaccharomyces pombe
- gsa1
In other databases
- LongevityMap
- This gene is present as GSS