GenAge entry for GPX1 (Homo sapiens)
Gene name (HAGRID: 153)
- HGNC symbol
- GPX1
- Aliases
- Common name
- glutathione peroxidase 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
Mostly present in erythrocytes, GPX1 protects from oxidative damage. Changes in GPX1 have been reported in mice during ageing and due to caloric restriction [243], but there is no direct evidence linking GPX1 to ageing. Mice without GPX1 are more susceptibility to oxidative stress, but do not show signs of premature ageing [741], except for cataracts [742]. Overexpression of GPX1 in mice results in insulin (INS) resistance and obesity [1066]. Results from transgenic mice overexpressing GPX1 in the heart suggest GPX1 could be beneficial to prevent cardiac failure [1711]. Its role, if any, in human ageing remains to be determined.
Cytogenetic information
- Cytogenetic band
- 3p21.3
- Location
- 49,357,176 bp to 49,358,358 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000302; response to reactive oxygen species
GO:0001659; temperature homeostasis
GO:0001885; endothelial cell development
GO:0002862; negative regulation of inflammatory response to antigenic stimulus
GO:0006195; purine nucleotide catabolic process
GO:0006641; triglyceride metabolic process
GO:0006749; glutathione metabolic process
GO:0007605; sensory perception of sound
GO:0008631; intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009410; response to xenobiotic stimulus
GO:0009609; response to symbiotic bacterium
And 31 more GO terms Cellular component: GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005759; mitochondrial matrix
GO:0005829; cytosol
GO:0070062; extracellular exosome
GO:0097413; Lewy body
Function: GO:0004602; glutathione peroxidase activity
GO:0017124; SH3 domain binding
Protein interactions and network
Retrieve sequences for GPX1
Homologs in model organisms
- Caenorhabditis elegans
- gpx-4
- Caenorhabditis elegans
- gpx-5
- Caenorhabditis elegans
- gpx-3
- Mus musculus
- Gpx1
- Rattus norvegicus
- Gpx1
- Saccharomyces cerevisiae
- HYR1
- Saccharomyces cerevisiae
- GPX1
In other databases
- LongevityMap
- This gene is present as GPX1