GenAge entry for GHRHR (Homo sapiens)
Gene name (HAGRID: 222)
- HGNC symbol
- GHRHR
- Aliases
- Common name
- growth hormone releasing hormone receptor
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
- Description
GHRHR is mostly expressed in the pituitary and functions as the receptor for GHRH. Different splice variants appear to exist. Knock-out mice without GHRHR, called little mice, live about 25% longer than controls [5], but it is unclear whether their ageing process is delayed. Mutations in the human GHRHR gene have been associated with growth deficiency and dwarfism [1751], though there is no indication that these patients live longer. GHRHR might play a role in human ageing through the GH1/IGF1 axis.
Cytogenetic information
- Cytogenetic band
- 7p14
- Location
- 30,964,021 bp to 30,979,531 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0007166; cell surface receptor signaling pathway
GO:0007189; adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190; activation of adenylate cyclase activity
GO:0007595; lactation
GO:0008284; positive regulation of cell proliferation
GO:0008340; determination of adult lifespan
GO:0019933; cAMP-mediated signaling
GO:0030104; water homeostasis
GO:0030252; growth hormone secretion
GO:0030819; positive regulation of cAMP biosynthetic process
GO:0032868; response to insulin
And 15 more GO terms Cellular component: GO:0005637; nuclear inner membrane
GO:0005640; nuclear outer membrane
GO:0005737; cytoplasm
GO:0005886; plasma membrane
GO:0009986; cell surface
GO:0016021; integral component of membrane
GO:0016363; nuclear matrix
GO:0030141; secretory granule
GO:0042383; sarcolemma
Function: GO:0004930; G-protein coupled receptor activity
GO:0005515; protein binding
GO:0016520; growth hormone-releasing hormone receptor activity
GO:0017046; peptide hormone binding
GO:0019838; growth factor binding
Protein interactions and network
Retrieve sequences for GHRHR
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Ghrhr
- LongevityMap
- This gene is present as GHRHR
Selected references
External links
- EPD
- ORF Accession
- NM_000823
- CDS Accession
- NP_000814
- OMIM
- 139191
- HPRD
- 00748
- Ensembl
- GHRHR
- UniProt/Swiss-Prot
- GHRHR_HUMAN
- GeneCards
- GHRHR
- Entrez Gene
- 2692
- GenAtlas
- GHRHR
- Internet
- Search Google