GenAge entry for GCLM (Homo sapiens)

Gene name (HAGRID: 238)

HGNC symbol: GCLM
Aliases: GLCLR
Common name: glutamate-cysteine ligase, modifier subunit

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description: Glutamate-cysteine ligase, composed of GCLC and GCLM, catalyses the first step in glutathione synthesis. Overexpression of GCLM in fruit flies extended mean and maximum lifespan by up to 50% [1551]. In humans, polymorphisms in GCLM have been associated with myocardial infarction [1555].

Cytogenetic information

Cytogenetic band: 1p22.1
Location: 93,885,200 bp to 93,909,598 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000096; sulfur amino acid metabolic process
GO:0006534; cysteine metabolic process
GO:0006536; glutamate metabolic process
GO:0006750; glutathione biosynthetic process
GO:0006979; response to oxidative stress
GO:0007568; aging
GO:0007584; response to nutrient
GO:0008637; apoptotic mitochondrial changes
GO:0014823; response to activity
GO:0035229; positive regulation of glutamate-cysteine ligase activity
GO:0035729; cellular response to hepatocyte growth factor stimulus

And 13 more GO terms

Cellular component:

GO:0005829; cytosol
GO:0017109; glutamate-cysteine ligase complex

Function:

GO:0004357; glutamate-cysteine ligase activity
GO:0030234; enzyme regulator activity
GO:0035226; glutamate-cysteine ligase catalytic subunit binding
GO:0046982; protein heterodimerization activity

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: EGFR, GCLC
STRING interaction network

Retrieve sequences for GCLM

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: E01A2.1
Danio rerio: gclm
Drosophila melanogaster: Gclm
Mus musculus: Gclm
Rattus norvegicus: Gclm
Schizosaccharomyces pombe: SPCC737.06c

In other databases

GenAge model organism genes

A homolog of this gene for Drosophila melanogaster is present as Gclm