GenAge entry for GCLC (Homo sapiens)
Gene name (HAGRID: 237)
- HGNC symbol
- GCLC
- Aliases
- GCS; GLCLC; GLCL
- Common name
- glutamate-cysteine ligase, catalytic subunit
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
Glutamate-cysteine ligase, composed of GCLC and GCLM, catalyses the first step in glutathione synthesis. Overexpression of GCLC in fruit flies extended their mean lifespan by 24% [1551]. In humans, mutations in GCLC have been related to hemolytic anemia [1553] and susceptibility to myocardial infarction [1554].
Cytogenetic information
- Cytogenetic band
- 6p12
- Location
- 53,497,341 bp to 53,545,129 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000096; sulfur amino acid metabolic process
GO:0006534; cysteine metabolic process
GO:0006536; glutamate metabolic process
GO:0006750; glutathione biosynthetic process
GO:0006979; response to oxidative stress
GO:0007568; aging
GO:0007584; response to nutrient
GO:0008637; apoptotic mitochondrial changes
GO:0009408; response to heat
GO:0009410; response to xenobiotic stimulus
GO:0009725; response to hormone
And 25 more GO terms Cellular component: GO:0005829; cytosol
GO:0017109; glutamate-cysteine ligase complex
Function: GO:0000287; magnesium ion binding
GO:0004357; glutamate-cysteine ligase activity
GO:0005524; ATP binding
GO:0016595; glutamate binding
GO:0043531; ADP binding
GO:0046982; protein heterodimerization activity
GO:0050662; coenzyme binding
Protein interactions and network
Retrieve sequences for GCLC
Homologs in model organisms
- Caenorhabditis elegans
- gcs-1
- Danio rerio
- gclc
- Drosophila melanogaster
- Gclc
- Mus musculus
- Gclc
- Rattus norvegicus
- Gclc
- Saccharomyces cerevisiae
- GSH1
- Schizosaccharomyces pombe
- gcs1
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Gclc
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as GSH1
- LongevityMap
- This gene is present as GCLC
Selected references
External links
- EPD
- ORF Accession
- NM_001498
- CDS Accession
- NP_001489
- OMIM
- 606857
- HPRD
- 06032
- Ensembl
- GCLC
- UniProt/Swiss-Prot
- GSH1_HUMAN
- GeneCards
- GCLC
- Entrez Gene
- 2729
- GenAtlas
- GCLC
- Internet
- Search Google