GenAge entry for GCLC (Homo sapiens)

Gene name (HAGRID: 237)

HGNC symbol
GCLC 
Aliases
GCS; GLCLC; GLCL 
Common name
glutamate-cysteine ligase, catalytic subunit 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Glutamate-cysteine ligase, composed of GCLC and GCLM, catalyses the first step in glutathione synthesis. Overexpression of GCLC in fruit flies extended their mean lifespan by 24% [1551]. In humans, mutations in GCLC have been related to hemolytic anemia [1553] and susceptibility to myocardial infarction [1554].

Cytogenetic information

Cytogenetic band
6p12
Location
53,497,341 bp to 53,545,129 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000096; sulfur amino acid metabolic process
GO:0006534; cysteine metabolic process
GO:0006536; glutamate metabolic process
GO:0006750; glutathione biosynthetic process
GO:0006979; response to oxidative stress
GO:0007568; aging
GO:0007584; response to nutrient
GO:0008637; apoptotic mitochondrial changes
GO:0009408; response to heat
GO:0009410; response to xenobiotic stimulus
GO:0009725; response to hormone
And 25 more GO terms
Cellular component: GO:0005829; cytosol
GO:0017109; glutamate-cysteine ligase complex
Function: GO:0000287; magnesium ion binding
GO:0004357; glutamate-cysteine ligase activity
GO:0005524; ATP binding
GO:0016595; glutamate binding
GO:0043531; ADP binding
GO:0046982; protein heterodimerization activity
GO:0050662; coenzyme binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
GCLM
STRING interaction network
Protein-Protein network diagram for GCLC

Retrieve sequences for GCLC

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
gcs-1
Danio rerio
gclc
Drosophila melanogaster
Gclc
Mus musculus
Gclc
Rattus norvegicus
Gclc
Saccharomyces cerevisiae
GSH1
Schizosaccharomyces pombe
gcs1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Gclc
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as GSH1
LongevityMap
  • This gene is present as GCLC

Selected references

External links

EPD
ORF Accession
NM_001498
CDS Accession
NP_001489
OMIM
606857
HPRD
06032
Ensembl
GCLC
UniProt/Swiss-Prot
GSH1_HUMAN
GeneCards
GCLC
Entrez Gene
2729
GenAtlas
GCLC
Internet
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