GenAge entry for FLT1 (Homo sapiens)
Gene name (HAGRID: 171)
- HGNC symbol
- FLT1
- Aliases
- VEGFR1; FLT
- Common name
- fms-related tyrosine kinase 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
Also known as VEGFR1, FLT1 is a receptor for VEGFA involved in its signalling cascade [975]. Mice without FLT1 die at embryonic stages [782]. In mouse skeletal muscle FLT1 expression levels have been reported to decline with age [1624]. FLT1 has not been directly related to human ageing.
Cytogenetic information
- Cytogenetic band
- 13q12
- Location
- 28,300,346 bp to 28,495,128 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0001525; angiogenesis
GO:0002548; monocyte chemotaxis
GO:0007169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284; positive regulation of cell proliferation
GO:0010863; positive regulation of phospholipase C activity
GO:0014068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477; cell migration
GO:0018108; peptidyl-tyrosine phosphorylation
GO:0030154; cell differentiation
GO:0030335; positive regulation of cell migration
GO:0030949; positive regulation of vascular endothelial growth factor receptor signaling pathway
And 12 more GO terms Cellular component: GO:0005615; extracellular space
GO:0005768; endosome
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0005925; focal adhesion
GO:0043235; receptor complex
Function: GO:0004714; transmembrane receptor protein tyrosine kinase activity
GO:0005021; vascular endothelial growth factor-activated receptor activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0019838; growth factor binding
GO:0036326; VEGF-A-activated receptor activity
GO:0036327; VEGF-B-activated receptor activity
GO:0036332; placental growth factor-activated receptor activity
Protein interactions and network
- Protein-protein interacting partners in GenAge
- SHC1, PTPN11, VEGFA, PIK3R1
- STRING interaction network
Retrieve sequences for FLT1
Homologs in model organisms
In other databases
- CellAge
- This gene is present as FLT1
Selected references
External links
- EPD
- ORF Accession
- NM_002019
- CDS Accession
- NP_002010
- OMIM
- 165070
- HPRD
- 01297
- Ensembl
- FLT1
- UniProt/Swiss-Prot
- VGFR1_HUMAN
- GeneCards
- FLT1
- Entrez Gene
- 2321
- GenAtlas
- FLT1
- Internet
- Search Google