GenAge entry for CTGF (Homo sapiens)
Gene name (HAGRID: 206)
- HGNC symbol
- CTGF
- Aliases
- IGFBP8; CCN2
- Common name
- connective tissue growth factor
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
CTGF is an important growth factor secreted by vascular endothelial cells. Overexpression of CTGF in mice resulted in dwarfism and decreased bone density [884]. Age-related upregulation of CTGF in senescent cells and in rat liver has also been reported [1737]. Further studies are necessary to determined whether CTGF influences human ageing.
Cytogenetic information
- Cytogenetic band
- 6q23.1
- Location
- 131,948,177 bp to 131,951,378 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0001502; cartilage condensation
GO:0001503; ossification
GO:0001525; angiogenesis
GO:0001558; regulation of cell growth
GO:0001894; tissue homeostasis
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0007155; cell adhesion
GO:0007160; cell-matrix adhesion
GO:0007229; integrin-mediated signaling pathway
GO:0007267; cell-cell signaling
GO:0007568; aging
And 34 more GO terms Cellular component: GO:0005576; extracellular region
GO:0005578; proteinaceous extracellular matrix
GO:0005615; extracellular space
GO:0005794; Golgi apparatus
GO:0005801; cis-Golgi network
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005938; cell cortex
GO:0043231; intracellular membrane-bounded organelle
GO:0048471; perinuclear region of cytoplasm
Function: GO:0001968; fibronectin binding
GO:0005178; integrin binding
GO:0005515; protein binding
GO:0005520; insulin-like growth factor binding
GO:0008022; protein C-terminus binding
GO:0008083; growth factor activity
GO:0008201; heparin binding
Protein interactions and network
Retrieve sequences for CTGF
Homologs in model organisms
In other databases
- GenAge microarray genes
- This gene is present as CCN2
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as Ctgf
- CellAge
- This gene is present as CCN2
- CellAge gene expression
- This gene is present as CTGF