GenAge entry for COQ7 (Homo sapiens)
Gene name (HAGRID: 132)
- HGNC symbol
- COQ7
- Aliases
- CLK-1; CAT5
- Common name
- coenzyme Q7 homolog, ubiquinone (yeast)
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
- Description
COQ7's functions are unclear, but it may be a metabolic regulator involved in several metabolic pathways such as the biosynthesis of ubiquinone, in turn an antioxidant involved in mitochondrial respiration [675]. In roundworms, the COQ7 homologue clk-1 affects developmental timing and lifespan [946]. Food restriction does not further increase the lifespan of long-lived clk-1 mutants, suggesting that clk-1 and caloric restriction affect similar processes [1820]. Knocking out COQ7 in mice results in developmental arrest at midgestation [1613]. Heterozygous mice live about 15 to 30% longer than controls, though it is unclear whether ageing is delayed [1612]. They also exhibit surprisingly high levels of oxidative damage and early mitochondrial dysfunction [2087]. Although it is possible for COQ7 to play a role in human ageing, further research is needed to investigate this possibility.
Cytogenetic information
- Cytogenetic band
- 16p12.3
- Location
- 19,067,595 bp to 19,080,095 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006744; ubiquinone biosynthetic process
GO:0055114; oxidation-reduction process
Cellular component: GO:0005634; nucleus
GO:0005743; mitochondrial inner membrane
Function: GO:0004497; monooxygenase activity
GO:0005515; protein binding
GO:0046872; metal ion binding
Protein interactions and network
Retrieve sequences for COQ7
Homologs in model organisms
- Caenorhabditis elegans
- clk-1
- Danio rerio
- coq7
- Drosophila melanogaster
- COQ7
- Mus musculus
- Coq7
- Rattus norvegicus
- Coq7
- Saccharomyces cerevisiae
- CAT5
- Schizosaccharomyces pombe
- coq7
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as clk-1
- LongevityMap
- This gene is present as COQ7
Selected references
External links
- EPD
- ORF Accession
- NM_016138
- CDS Accession
- NP_057222
- OMIM
- 601683
- HPRD
- 03401
- Ensembl
- COQ7
- UniProt/Swiss-Prot
- COQ7_HUMAN
- GeneCards
- COQ7
- Entrez Gene
- 10229
- GenAtlas
- COQ7
- Internet
- Search Google