GenAge entry for CNR1 (Homo sapiens)
Gene name (HAGRID: 282)
- HGNC symbol
- CNR1
- Aliases
- CB1K5; CB-R; CB1; CANN6; CB1A; CNR
- Common name
- cannabinoid receptor 1 (brain)
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
The CNR1 genes encodes for the cannabinoid receptor 1 (CB1) and is involved in cannabinoid-induced central nervous system effects. Mice lacking the Cnr1 gene showed an accelerated age-dependent deficit in spatial learning accompanied by a loss of principal neurons in the hippocampus and enhanced neuroinflammation suggesting that CB1 receptor activity on hippocampal GABAergic neurons protects against age-dependent cognitive decline by reducing pyramidal cell degeneration and neuroinflammation [2206]. In human cells, the CB1 receptors have been linked to neurodegenerative [2207] and macular degeneration [2208]. Genome wide association studies found that genetic variants of CNR1 may be associated with obesity-related phenotypes in humans [2209]. Clearly, CNR1 appears to be related to neurodegenerative diseases, however, its role in broader aspects of ageing is unclear.
Cytogenetic information
- Cytogenetic band
- 6q14-q15
- Location
- 88,139,865 bp to 88,166,048 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0002866; positive regulation of acute inflammatory response to antigenic stimulus
GO:0007187; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188; adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007283; spermatogenesis
GO:0007413; axonal fasciculation
GO:0007568; aging
GO:0007584; response to nutrient
GO:0007613; memory
GO:0010976; positive regulation of neuron projection development
GO:0019233; sensory perception of pain
GO:0031622; positive regulation of fever generation
And 22 more GO terms Cellular component: GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0030424; axon
GO:0030426; growth cone
GO:0043231; intracellular membrane-bounded organelle
GO:0045121; membrane raft
Function: GO:0004949; cannabinoid receptor activity
GO:0008144; drug binding
Protein interactions and network
No interactions in records.
Retrieve sequences for CNR1
Homologs in model organisms
In other databases
- LongevityMap
- This gene is present as CNR1
Selected references
External links
- EPD
- ORF Accession
- NM_001160226
- CDS Accession
- NP_001153698
- OMIM
- 114610
- HPRD
- 00259
- Ensembl
- CNR1
- UniProt/Swiss-Prot
- CNR1_HUMAN
- GeneCards
- CNR1
- Entrez Gene
- 1268
- GenAtlas
- CNR1
- Internet
- Search Google