GenAge entry for CNR1 (Homo sapiens)

Gene name (HAGRID: 282)

HGNC symbol
CNR1 
Aliases
CB1K5; CB-R; CB1; CANN6; CB1A; CNR 
Common name
cannabinoid receptor 1 (brain) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

The CNR1 genes encodes for the cannabinoid receptor 1 (CB1) and is involved in cannabinoid-induced central nervous system effects. Mice lacking the Cnr1 gene showed an accelerated age-dependent deficit in spatial learning accompanied by a loss of principal neurons in the hippocampus and enhanced neuroinflammation suggesting that CB1 receptor activity on hippocampal GABAergic neurons protects against age-dependent cognitive decline by reducing pyramidal cell degeneration and neuroinflammation [2206]. In human cells, the CB1 receptors have been linked to neurodegenerative [2207] and macular degeneration [2208]. Genome wide association studies found that genetic variants of CNR1 may be associated with obesity-related phenotypes in humans [2209]. Clearly, CNR1 appears to be related to neurodegenerative diseases, however, its role in broader aspects of ageing is unclear.

Cytogenetic information

Cytogenetic band
6q14-q15
Location
88,139,865 bp to 88,166,048 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0002866; positive regulation of acute inflammatory response to antigenic stimulus
GO:0007187; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188; adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007283; spermatogenesis
GO:0007413; axonal fasciculation
GO:0007568; aging
GO:0007584; response to nutrient
GO:0007613; memory
GO:0010976; positive regulation of neuron projection development
GO:0019233; sensory perception of pain
GO:0031622; positive regulation of fever generation
And 22 more GO terms
Cellular component: GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0030424; axon
GO:0030426; growth cone
GO:0043231; intracellular membrane-bounded organelle
GO:0045121; membrane raft
Function: GO:0004949; cannabinoid receptor activity
GO:0008144; drug binding
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for CNR1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
cnr1
Mus musculus
Cnr1
Rattus norvegicus
Cnr1

In other databases

LongevityMap
  • This gene is present as CNR1

Selected references

External links

EPD
ORF Accession
NM_001160226
CDS Accession
NP_001153698
OMIM
114610
HPRD
00259
Ensembl
CNR1
UniProt/Swiss-Prot
CNR1_HUMAN
GeneCards
CNR1
Entrez Gene
1268
GenAtlas
CNR1
Internet
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