GenAge entry for CETP (Homo sapiens)
Gene name (HAGRID: 262)
- HGNC symbol
- CETP
- Aliases
- BPIFF
- Common name
- cholesteryl ester transfer protein, plasma
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene or its product to human longevity and/or multiple age-related phenotypes
- Description
The cholesteryl ester transfer protein (CETP) is a protein involved in the transfer of cholesteryl esters between lipoproteins. CETP is a crucial protein involved in the regulation of high density lipoprotein (HDL) levels and may affect susceptibility to age-related diseases, including atherosclerosis and Alzheimer's Disease (AD). A higher HDL/LDL ratio has been associated with healthier and longer-lived individuals. Accordingly, a polymorphism (I405V) in the CETP gene has been associated with longevity in some long-lived populations of healthy aging Ashkenazi Jews [2127] as well as in a cohort of Greek individuals [2128]. This however was not observed in a similar study with Italian centenaries [2129] and it appears that this polymorphism is not enough to universally determine longevity and other genes might play an important role.
CETP has been also associated with susceptibility to age-related diseases. For example, it was suggested that CETP behaves as a modifier gene of the AD risk associated with APOE [2130] and that the I405V polymorphism is associated with an increased risk of AD [2131]. CETP has been also identified as a susceptibility allele for advanced age-related macular degeneration [2133].
Cytogenetic information
- Cytogenetic band
- 16q21
- Location
- 56,961,923 bp to 56,983,844 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006641; triglyceride metabolic process
GO:0006869; lipid transport
GO:0006898; receptor-mediated endocytosis
GO:0008203; cholesterol metabolic process
GO:0010745; negative regulation of macrophage derived foam cell differentiation
GO:0010874; regulation of cholesterol efflux
GO:0015914; phospholipid transport
GO:0030301; cholesterol transport
GO:0034197; triglyceride transport
GO:0034372; very-low-density lipoprotein particle remodeling
GO:0034374; low-density lipoprotein particle remodeling
And 9 more GO terms Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0031982; vesicle
GO:0034364; high-density lipoprotein particle
GO:0070062; extracellular exosome
Function: GO:0005319; lipid transporter activity
GO:0005548; phospholipid transporter activity
GO:0008289; lipid binding
GO:0015485; cholesterol binding
GO:0017127; cholesterol transporter activity
GO:0017129; triglyceride binding
GO:0031210; phosphatidylcholine binding
Protein interactions and network
No interactions in records.
Retrieve sequences for CETP
Homologs in model organisms
- Danio rerio
- cetp
In other databases
- LongevityMap
- This gene is present as CETP
Selected references
External links
- EPD
- ORF Accession
- NM_000078
- CDS Accession
- NP_000069
- OMIM
- 118470
- HPRD
- 00325
- Ensembl
- CETP
- UniProt/Swiss-Prot
- CETP_HUMAN
- GeneCards
- CETP
- Entrez Gene
- 1071
- GenAtlas
- CETP
- Internet
- Search Google