GenAge entry for CETP (Homo sapiens)

Gene name (HAGRID: 262)

HGNC symbol
CETP 
Aliases
BPIFF 
Common name
cholesteryl ester transfer protein, plasma 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene or its product to human longevity and/or multiple age-related phenotypes
Description

The cholesteryl ester transfer protein (CETP) is a protein involved in the transfer of cholesteryl esters between lipoproteins. CETP is a crucial protein involved in the regulation of high density lipoprotein (HDL) levels and may affect susceptibility to age-related diseases, including atherosclerosis and Alzheimer's Disease (AD). A higher HDL/LDL ratio has been associated with healthier and longer-lived individuals. Accordingly, a polymorphism (I405V) in the CETP gene has been associated with longevity in some long-lived populations of healthy aging Ashkenazi Jews [2127] as well as in a cohort of Greek individuals [2128]. This however was not observed in a similar study with Italian centenaries [2129] and it appears that this polymorphism is not enough to universally determine longevity and other genes might play an important role.

CETP has been also associated with susceptibility to age-related diseases. For example, it was suggested that CETP behaves as a modifier gene of the AD risk associated with APOE [2130] and that the I405V polymorphism is associated with an increased risk of AD [2131]. CETP has been also identified as a susceptibility allele for advanced age-related macular degeneration [2133].

Cytogenetic information

Cytogenetic band
16q21
Location
56,961,923 bp to 56,983,844 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006641; triglyceride metabolic process
GO:0006869; lipid transport
GO:0006898; receptor-mediated endocytosis
GO:0008203; cholesterol metabolic process
GO:0010745; negative regulation of macrophage derived foam cell differentiation
GO:0010874; regulation of cholesterol efflux
GO:0015914; phospholipid transport
GO:0030301; cholesterol transport
GO:0034197; triglyceride transport
GO:0034372; very-low-density lipoprotein particle remodeling
GO:0034374; low-density lipoprotein particle remodeling
And 9 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0031982; vesicle
GO:0034364; high-density lipoprotein particle
GO:0070062; extracellular exosome
Function: GO:0005319; lipid transporter activity
GO:0005548; phospholipid transporter activity
GO:0008289; lipid binding
GO:0015485; cholesterol binding
GO:0017127; cholesterol transporter activity
GO:0017129; triglyceride binding
GO:0031210; phosphatidylcholine binding
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for CETP

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
cetp

In other databases

LongevityMap
  • This gene is present as CETP

Selected references

External links

EPD
ORF Accession
NM_000078
CDS Accession
NP_000069
OMIM
118470
HPRD
00325
Ensembl
CETP
UniProt/Swiss-Prot
CETP_HUMAN
GeneCards
CETP
Entrez Gene
1071
GenAtlas
CETP
Internet
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