GenAge entry for BMI1 (Homo sapiens)
Gene name (HAGRID: 188)
- HGNC symbol
- BMI1
- Aliases
- RNF51; PCGF4
- Common name
- BMI1 proto-oncogene, polycomb ring finger
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
BMI1 is an oncogene involved in transcriptional regulation by remodelling chromatin. It may also be involved in development. Overexpression of BMI1 in mice results in transformation of axial skeleton [813]. BMI1-null mice show reduced self-renewal of neural stem cells [811], and thus a role for BMI1 in stem cell senescence has been proposed [1402]. Bmi-1 is downregulated in the aging brain [3325]. Additionally, brains of 8 month old Bmi-1 heterozygous knockout mice display mild oxidative stress through significant increases in hydroxy radical and nitrotyrosine compared with wild-type littermates. The hippocampus of these mice has also a high apoptotic percentage and lipofuscin depositions in pyramidal neurons. Behaviorally, the mice show mild spatial memory impairment, suggesting an early onset of age-related brain changes [3582]. It has also been suggested that Bmi-1 is important for the maintenance of redox balance resulting in a protective role against renal tubulointerstitial injury [3583]. Whether BMI1 impacts on human ageing remains to be determined.
Cytogenetic information
- Cytogenetic band
- 10p11.23
- Location
- 22,321,210 bp to 22,331,485 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006351; transcription, DNA-templated
GO:0007379; segment specification
GO:0010468; regulation of gene expression
GO:0016569; covalent chromatin modification
GO:0016925; protein sumoylation
GO:0030097; hemopoiesis
GO:0045814; negative regulation of gene expression, epigenetic
GO:0048146; positive regulation of fibroblast proliferation
GO:0051443; positive regulation of ubiquitin-protein transferase activity
Cellular component: GO:0000151; ubiquitin ligase complex
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0031519; PcG protein complex
GO:0035102; PRC1 complex
Function: GO:0005515; protein binding
GO:0008270; zinc ion binding
GO:0071535; RING-like zinc finger domain binding
GO:1990841; promoter-specific chromatin binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, ATM, NBN, PARP1, PTEN, CREBBP, TOP2A, UBE2I, EP300, PRKDC, AR, XRCC5, TERF2, AIFM1, HSPA1A, MAPK14, BMI1, H2AFX, DBN1, SOCS2, PYCR1
- STRING interaction network
Retrieve sequences for BMI1
Homologs in model organisms
- Danio rerio
- bmi1b
- Danio rerio
- bmi1a
- Drosophila melanogaster
- Su(z)2
- Drosophila melanogaster
- Psc
- Mus musculus
- Bmi1
- Rattus norvegicus
- Bmi1
In other databases
- CellAge
- This gene is present as BMI1
Selected references
External links
- EPD
- ORF Accession
- NM_005180
- CDS Accession
- NP_005171
- OMIM
- 164831
- HPRD
- 01277
- Ensembl
- BMI1
- UniProt/Swiss-Prot
- BMI1_HUMAN
- GeneCards
- BMI1
- Entrez Gene
- 648
- GenAtlas
- BMI1
- Internet
- Search Google