GenAge entry for BDNF (Homo sapiens)
Gene name (HAGRID: 191)
- HGNC symbol
- BDNF
- Aliases
- Common name
- brain-derived neurotrophic factor
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
BDNF is a growth factor that promotes neuronal survival and is involved in numerous neuronal responses.
Mice with an accelerated postnatal rise in BDNF showed a precocious development of some CNS features [833]. BDNF-deficient mice showed normal levels of serotonergic neurons at an early age but premature age-associated decrements [834]. Polymorphisms in the human BDNF gene have been associated with memory and hippocampal function [1727]. Age-related changes in BDNF have also been reported in rats [59]. In rats, BDNF has also been associated with changes in the heart [1646]. Although it is plausible that BDNF plays a role in some age-related pathologies, such as neurodegenerative diseases, its impact on human ageing has not been elucidated.
Cytogenetic information
- Cytogenetic band
- 11p13
- Location
- 27,654,895 bp to 27,659,649 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0007267; cell-cell signaling
GO:0007399; nervous system development
GO:0007411; axon guidance
GO:0007416; synapse assembly
GO:0010832; negative regulation of myotube differentiation
GO:0031547; brain-derived neurotrophic factor receptor signaling pathway
GO:0031550; positive regulation of brain-derived neurotrophic factor receptor signaling pathway
GO:0043524; negative regulation of neuron apoptotic process
GO:0048668; collateral sprouting
GO:0048672; positive regulation of collateral sprouting
GO:0051965; positive regulation of synapse assembly
And 3 more GO terms Cellular component: GO:0005576; extracellular region
GO:0005737; cytoplasm
GO:0048471; perinuclear region of cytoplasm
Function: GO:0005169; neurotrophin TRKB receptor binding
GO:0008083; growth factor activity
Protein interactions and network
Retrieve sequences for BDNF
Homologs in model organisms
Selected references
External links
- EPD
- ORF Accession
- NM_170735
- CDS Accession
- NP_733931
- OMIM
- 113505
- HPRD
- 00214
- Ensembl
- BDNF
- UniProt/Swiss-Prot
- BDNF_HUMAN
- GeneCards
- BDNF
- Entrez Gene
- 627
- GenAtlas
- BDNF
- Internet
- Search Google