GenAge entry for BAX (Homo sapiens)
Gene name (HAGRID: 119)
- HGNC symbol
- BAX
- Aliases
- BCL2L4
- Common name
- BCL2-associated X protein
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
An important player in apoptosis, BAX encodes multiple transcripts and has been linked to development, cancer, and age-related changes in apoptosis [600]. Inactivation of BAX in mice extended fertile potential and minimized age-related health problems, including bone and muscle loss, excess fat deposition, alopecia, cataracts, deafness, increased anxiety, and selective attention deficit. It did not extend lifespan [1927]. Changes in apoptotic proteins like BAX could also contribute to ageing-associated atrophy in the skeletal muscle of rats [1639]. It is not known how these processes are related to human ageing, but a role of BAX in human ageing is a possibility.
Cytogenetic information
- Cytogenetic band
- 19q13.3-q1
- Location
- 48,954,860 bp to 48,961,262 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0001541; ovarian follicle development
GO:0001764; neuron migration
GO:0001777; T cell homeostatic proliferation
GO:0001782; B cell homeostasis
GO:0001783; B cell apoptotic process
GO:0001822; kidney development
GO:0001836; release of cytochrome c from mitochondria
GO:0001844; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001974; blood vessel remodeling
GO:0002262; myeloid cell homeostasis
GO:0002352; B cell negative selection
And 78 more GO terms Cellular component: GO:0005634; nucleus
GO:0005635; nuclear envelope
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005741; mitochondrial outer membrane
GO:0005757; mitochondrial permeability transition pore complex
GO:0005783; endoplasmic reticulum
GO:0005789; endoplasmic reticulum membrane
GO:0005829; cytosol
GO:0016020; membrane
GO:0046930; pore complex
And 4 more GO terms Function: GO:0005515; protein binding
GO:0008289; lipid binding
GO:0015267; channel activity
GO:0030544; Hsp70 protein binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0046982; protein heterodimerization activity
GO:0051087; chaperone binding
GO:0051434; BH3 domain binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, BCL2, VCP, ERCC6, XRCC5, XRCC6, BAX, PRDX1, HSPD1, CLU, KCNA3, BAK1
- STRING interaction network
Retrieve sequences for BAX
Homologs in model organisms
- Danio rerio
- baxb
- Danio rerio
- baxa
- Danio rerio
- BX511080.1
- Danio rerio
- baxa
- Mus musculus
- Bax
- Rattus norvegicus
- Bax
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Bax
- LongevityMap
- This gene is present as BAX