GenAge entry for AGTR1 (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 264)
- HGNC symbol
- AGTR1
- Aliases
- AT1; AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B
- Common name
- angiotensin II receptor, type 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
AGTR1 is a gene encoding for one of the Ang II type 1 receptors. Ang II is the central product of the renin-angiotensin system and plays a role in cardiac and renal pathologies. Disruption of AGTR1 in mice resulted in a significant prolongation of maximal lifespan compared to controls. The mice also developed less cardiac and vascular injury, and multiple organs from these mice displayed less oxidative damage [2148]. AGTR1 is involved in atherosclerosis [2151] and renal diseases [2152].
Cytogenetic information
- Cytogenetic band
- 3q24
- Location
- 148,697,871 bp to 148,743,003 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0001558; regulation of cell growth
GO:0001822; kidney development
GO:0002018; renin-angiotensin regulation of aldosterone production
GO:0002034; regulation of blood vessel diameter by renin-angiotensin
GO:0003081; regulation of systemic arterial blood pressure by renin-angiotensin
GO:0007186; G-protein coupled receptor signaling pathway
GO:0007200; phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204; positive regulation of cytosolic calcium ion concentration
GO:0007266; Rho protein signal transduction
GO:0010744; positive regulation of macrophage derived foam cell differentiation
GO:0010873; positive regulation of cholesterol esterification
And 17 more GO terms Cellular component: GO:0005622; intracellular
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0016021; integral component of membrane
Function: GO:0001596; angiotensin type I receptor activity
GO:0004945; angiotensin type II receptor activity
GO:0005515; protein binding
GO:0031711; bradykinin receptor binding
GO:0046982; protein heterodimerization activity
Protein interactions and network
Retrieve sequences for AGTR1
Homologs in model organisms
- Danio rerio
- agtr1a
- Danio rerio
- agtr1b
- Mus musculus
- Agtr1b
- Mus musculus
- Agtr1a
- Rattus norvegicus
- Agtr1a
- Rattus norvegicus
- Agtr1b
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Agtr1a
- LongevityMap
- This gene is present as AGTR1
Selected references
External links
- EPD
- ORF Accession
- NM_000685
- CDS Accession
- NP_000676
- OMIM
- 106165
- HPRD
- 00107
- Ensembl
- AGTR1
- UniProt/Swiss-Prot
- AGTR1_HUMAN
- GeneCards
- AGTR1
- Entrez Gene
- 185
- GenAtlas
- AGTR1
- Internet
- Search Google