Caenorhabditis elegansGenAge entry for egl-30 (Caenorhabditis elegans)

Gene information (ID: 919)

Symbol
egl-30
Name
EGg Laying defective
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
Egl-30 mutants (reduction-of-function) showed a 31% median lifespan extension (in the daf-16 background) and a 38% median lifespan extension (compared to wild type). Conversely, egl-30 (gain-of-function) constitutively active Gaq mutants were short-lived.
% change in avg or median lifespan
Median lifespan is 38% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference
    Observations
    15% mean lifespan extension
    % change in avg or median lifespan
    Average lifespan is 15% higher.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Mutation
    Longevity Category
    Anti-Longevity
    Primary reference

      In other databases

      GenAge model organism genes
      • A homolog of this gene for Saccharomyces cerevisiae is present as GPA2
      GenDR gene manipulations
      • A homolog of this gene for Saccharomyces cerevisiae is present as GPA2

      Homologs in other organisms

      Danio rerio
      gnaq
      Danio rerio
      gna11b
      Danio rerio
      gna11a
      Drosophila melanogaster
      CG30054
      Drosophila melanogaster
      CG17760
      Drosophila melanogaster
      Galphaq
      Homo sapiens
      GNA11
      Homo sapiens
      GNAQ
      Mus musculus
      Gnaq
      Mus musculus
      Gna11
      Rattus norvegicus
      Gna11
      Rattus norvegicus
      Gnaq
      Saccharomyces cerevisiae
      GPA2

      External links

      WormBase
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      Ensembl
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      Entrez Gene
      View on Entrez Gene database (171751)
      Homologues
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      UniProt
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      Internet
      Search Google or Search Google Scholar