- Symbol
- Hsp22
- Aliases
- 22; anon-WO0118547.50; anon-WO0140519.138; CG32041; CG
- Name
- Heat shock protein 22
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- Overexpression increases mean lifespan by more than 30% and increases the premortality phase.
- % change in avg or median lifespan
- Average lifespan is more than 30% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- TSA (Histone deacetylase (HDAC) inhibitor Trichostatin A (TSA)) could extend the lifespan of Drosophila melanogaster by promoting the hsp22 gene transcription, and affecting the chromatin morphology at the locus of hsp22 gene along the polytene chromosome.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Epigenetic modification
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Mean lifespan was reduced up to 21% upon doxycycline-regulated overexpression of Hsp22, particularly at higher culture temperatures.
- % change in avg or median lifespan
- Average lifespan is up to 21% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Overexpression
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Reduced mean and maximal lifespan when overexpressed
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Overexpression
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as hsp-16.1
- A homolog of this gene for Caenorhabditis elegans is present as hsp-16.48
- A homolog of this gene for Caenorhabditis elegans is present as hsp-16.49
- A homolog of this gene for Caenorhabditis elegans is present as sip-1
- GenAge microarray genes
- A homolog of this gene for Homo sapiens is present as CRYAB
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as CRYAB
- Caenorhabditis elegans
- hsp-16.49
- Caenorhabditis elegans
- hsp-16.1
- Caenorhabditis elegans
- hsp-16.48
- Caenorhabditis elegans
- hsp-16.49
- Caenorhabditis elegans
- hsp-16.48
- Caenorhabditis elegans
- hsp-16.11
- Caenorhabditis elegans
- hsp-43
- Caenorhabditis elegans
- Y55F3BR.6
- Caenorhabditis elegans
- hsp-17
- Caenorhabditis elegans
- F08H9.4
- Caenorhabditis elegans
- F08H9.3
- Caenorhabditis elegans
- hsp-16.1
- Caenorhabditis elegans
- hsp-16.11
- Caenorhabditis elegans
- hsp-16.41
- Caenorhabditis elegans
- hsp-16.2
- Caenorhabditis elegans
- sip-1
- Danio rerio
- hspb6
- Danio rerio
- cryabb
- Danio rerio
- cryaba
- Danio rerio
- cryaa
- Homo sapiens
- CRYAB
- Homo sapiens
- 102724652
- Homo sapiens
- HSPB6
- Homo sapiens
- CRYAA
- Mus musculus
- Hspb6
- Mus musculus
- Cryaa
- Mus musculus
- Cryab
- Rattus norvegicus
- Cryab
- Rattus norvegicus
- Hspb6
- Rattus norvegicus
- Cryaa
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (3772576)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Hsp22 (Drosophila melanogaster)