- Symbol
- Pparg
- Aliases
- Nr1c3; PPARgamma; PPAR-gamma; PPARgamma2; PPAR-gamma2
- Name
- Peroxisome proliferator activated receptor gamma
- Organism
- Mus musculus (AnAge)
- Observations
- On a chow diet, despite equal food intake, Ala/Ala knock-in mice display beneficial changes in fat mass, circulating lipids, and insulin sensitivity, compared to their Pro/Pro littermates. Ala/Ala mice also gained less weight than Pro/Pro mice both in fat and lean body mass, and their lifespan is average 13% longer.
- % change in avg or median lifespan
- Average lifespan is 13% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Knockin
- Primary reference
-
- Observations
- Lowered expression of Pparg reduced lifespan in both the lipodystrophic Pparg1/2-hypomorphic and the Pparg2-deficient mice.
- % change in avg or median lifespan
- Median lifespan is approximately 11% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutations
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as PPARG
- LongevityMap
- A homolog of this gene for Homo sapiens is present as PPARG
- CellAge
- A homolog of this gene for Homo sapiens is present as PPARG
- Caenorhabditis elegans
- nhr-38
- Caenorhabditis elegans
- sex-1
- Danio rerio
- pparg
- Homo sapiens
- PPARG
- Rattus norvegicus
- Pparg
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (19016)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Pparg (Mus musculus)