- Symbol
- Sirt6
- Aliases
- Sir2l6; AI043036; 2810449N18Rik
- Name
- sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae)
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- NAD(+)-dependent histone deacetylase that silences gene expression
- Observations
- Overexpression of Sirt6 in mice increases lifespan by 10-14.5% in males, but not in females. Males also had lower levels of IGF1.
- % change in max lifespan
- Maximum lifespan is 14.5% higher.
- % change in avg or median lifespan
- Average lifespan is 12% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Knockout mice develop signs of premature ageing including a short lifespan.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as SIRT6
- LongevityMap
- A homolog of this gene for Homo sapiens is present as SIRT6
- CellAge
- A homolog of this gene for Homo sapiens is present as SIRT6
- Caenorhabditis elegans
- sir-2.4
- Danio rerio
- SIRT6
- Drosophila melanogaster
- Sirt6
- Homo sapiens
- SIRT6
- Rattus norvegicus
- Sirt6
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (50721)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Sirt6 (Mus musculus)