- Symbol
- Plau
- Aliases
- uPA; u-PA
- Name
- Plasminogen activator, urokinase
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- A protease that converts plasminogen to plasmin
- Observations
- Overexpression in the brain of transgenic mice resulted in less food consumption (20%), reduced body weight (20%), reduced temperature, and a prolonged lifespan (20%).
- % change in avg or median lifespan
- Lifespan is 20% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as PLAU
- Caenorhabditis elegans
- svh-1
- Danio rerio
- plaub
- Danio rerio
- plaua
- Homo sapiens
- PLAU
- Rattus norvegicus
- Plau
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (18792)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Plau (Mus musculus)