Mus musculusGenAge entry for Pou1f1 (Mus musculus)

Gene information (ID: 506)

Symbol
Pou1f1
Aliases
dw; Hmp1; Pit1; GHF-1; Pit-1; dwarf; Pit1-rs1
Name
POU domain, class 1, transcription factor 1
Organism
Mus musculus (AnAge)
Known functions and activities
Transcription factor that regulates pituitary development

Potential relevance to longevity and/or ageing

Observations
Deletion resulted in more than 40% increase in mean and maximal longevity on the relatively long-lived (C3H/HeJ x DW/J)F(1) background.
% change in max lifespan
Maximum lifespan is more than 40% higher.
% change in avg or median lifespan
Average lifespan is more than 40% higher.
Lifespan Effect
Increase
Genetic Manipulation
Deletion
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as POU1F1

    Homologs in other organisms

    Danio rerio
    pou1f1
    Homo sapiens
    POU1F1
    Rattus norvegicus
    Pou1f1

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (18736)
    Homologues
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    UniProt
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    Internet
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