- Symbol
- Kl
- Aliases
- alpha-kl
- Name
- Klotho
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Calcium metabolism
- Observations
- Disruption results in infertility and signs of premature ageing such as a short lifespan, arteriosclerosis, skin atrophy, osteoporosis, and emphysema.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Overexpression of Klotho in mice extends life span
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Many advanced ageing-like KL -/- phenotypes are restored to normal whenever Klotho expression is induced. Conversely, decreasing Klotho expression in these rescued KL -/- mice induced several ageing-like KL -/- phenotypes.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Conditional knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as klo-1
- A homolog of this gene for Caenorhabditis elegans is present as klo-2
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as KL
- LongevityMap
- A homolog of this gene for Homo sapiens is present as KL
- CellAge
- A homolog of this gene for Homo sapiens is present as KL
- Caenorhabditis elegans
- klo-2
- Caenorhabditis elegans
- klo-1
- Danio rerio
- kl
- Homo sapiens
- KL
- Rattus norvegicus
- Kl
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (16591)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Kl (Mus musculus)