- Symbol
- Igf1
- Aliases
- Igf-1; Igf-I; C730016P09Rik
- Name
- Insulin-like growth factor 1
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Hormone that stimulates growth
- Observations
- Homozygous Igf1-deficient (gene insertion resulting in reduced levels of IGF-1) display an overall significantly increased maximum lifespan, but not an increased mean lifespan. It should also be noted that variation in the mortality rates exists between cohorts (possibly due to breeding differences) and sexes.
- % change in max lifespan
- Maximum lifespan is up to 12% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Mutation
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Congenital liver IGF-1-deficient mice, which have a low serum IGF-1 throughout lifespan, display a ~20% lifespan reduction for males compared to wild-type controls, with no changes in female lifespan. Male mutants also showed decreased body weight, increased liver weight, reduced kidney and quadriceps weight, and an overall increase in the incidence of neoplasms.
- % change in avg or median lifespan
- Mean lifespan is approximately 20% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Cardiac specific overexpression results in a 23% increase in median lifespan, though no increase in maximum lifespan.
- % change in max lifespan
- No increase in maximum lifespan
- % change in avg or median lifespan
- Median lifespan is 23% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as IGF1
- GenAge microarray genes
- A homolog of this gene for Homo sapiens is present as IGF1
- LongevityMap
- A homolog of this gene for Homo sapiens is present as IGF1
- Danio rerio
- igf1
- Homo sapiens
- IGF1
- Rattus norvegicus
- Igf1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (16000)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Igf1 (Mus musculus)