- Symbol
- Atr
- Name
- Ataxia telangiectasia and Rad3 related
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- DNA repair and cell cycle control
- Observations
- Deletion in young adults eliminates 80-90% of proliferating cells and results in several age-related phenotypes accompanied by a depletion of stem and progenitor cells and exhaustion of tissue renewal and homeostatic capacity.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Deletion
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Mutant mice show high levels of replicative stress during embryogenesis, when proliferation is widespread, but this is reduced to marginal amounts in postnatal life. In spite of this decrease, adult Seckel mice show accelerated aging, which is further aggravated in the absence of p53. Seckel mice died in less than half a year, showing pancytopenia, cachexia and signs of premature ageing, including hair graying, kyphosis, osteoporosis, accumulation of fat in the bone marrow, decreased density of hair follicles and thinner epidermis.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutations
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as MEC1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as ATR
- LongevityMap
- A homolog of this gene for Homo sapiens is present as ATR
- CellAge
- A homolog of this gene for Homo sapiens is present as ATR
- Danio rerio
- atr
- Drosophila melanogaster
- mei-41
- Homo sapiens
- ATR
- Rattus norvegicus
- Atr
- Saccharomyces cerevisiae
- MEC1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (245000)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Atr (Mus musculus)