- Symbol
- mfn-1
- Name
- Protein MFN-1
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Reduction of mitoferrin through RNAi results in small body size, reduced fecundity, slow movement and increased sensitivity to paraquat, but also in an increased lifespan of 50% to 80% compared to the N2 wild type worms strain.
- % change in max lifespan
- Maximum lifespan is up to 77% higher.
- % change in avg or median lifespan
- Average lifespan is up to 64% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as MRS4
- Danio rerio
- slc25a37
- Danio rerio
- slc25a28
- Drosophila melanogaster
- mfrn
- Homo sapiens
- SLC25A28
- Homo sapiens
- SLC25A37
- Mus musculus
- Slc25a28
- Mus musculus
- Gm16867
- Mus musculus
- Slc25a37
- Rattus norvegicus
- Slc25a37
- Rattus norvegicus
- Slc25a28
- Saccharomyces cerevisiae
- MRS3
- Saccharomyces cerevisiae
- MRS4
- Schizosaccharomyces pombe
- SPAC8C9.12c
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (174752)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar