- Symbol
- xbp-1
- Name
- Protein XBP-1
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Ubiquitous expression of xbp-1s did not extend lifespan, despite increasing ER stress resistance. Neuronal xbp-1s transgenic animals had a surprising and significant extension of longevity (20-30%). Expression in the intestine also resulted in an increase longevity by 20%, whereas expression in the muscle cells shortened lifespan by 25%.
- Lifespan Effect
- Not Recorded
- Genetic Manipulation
- Overexpression
- Longevity Category
- Not Recorded
- Primary reference
-
- Danio rerio
- xbp1
- Drosophila melanogaster
- Xbp1
- Homo sapiens
- XBP1
- Mus musculus
- Xbp1
- Rattus norvegicus
- Xbp1
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (175541)
- Homologues
- Search HomoloGene
- UniProt
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- Internet
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GenAge entry for xbp-1 (Caenorhabditis elegans)