- Symbol
- wwp-1
- Name
- WW domain Protein (E3 ubiquitin ligase)
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- Ubiquitin-protein ligase
- Observations
- RNA interference of wwp-1 results in reduced lifespan at 25 degrees (but not at 20 degrees). Transgenic overexpression of wwp-1 results in a 20% increase in lifespan.
- % change in avg or median lifespan
- Lifespan is 20% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- RNA interference decreased median lifespan by 9% in wild type animals and 24% in daf-2 mutants.
- % change in avg or median lifespan
- Median lifespan is 9% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenDR gene manipulations
- This gene is present as wwp-1
- CellAge
- A homolog of this gene for Homo sapiens is present as WWP1
- Danio rerio
- wwp2
- Danio rerio
- wwp1
- Danio rerio
- itchb
- Danio rerio
- itcha
- Drosophila melanogaster
- Su(dx)
- Homo sapiens
- WWP1
- Homo sapiens
- WWP2
- Homo sapiens
- ITCH
- Mus musculus
- Wwp1
- Mus musculus
- Wwp2
- Mus musculus
- Itch
- Rattus norvegicus
- Wwp1
- Rattus norvegicus
- Wwp2
- Rattus norvegicus
- Itch
- Saccharomyces cerevisiae
- RSP5
- Schizosaccharomyces pombe
- pub1
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (171647)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for wwp-1 (Caenorhabditis elegans)