GenAge entry for vhl-1 (Caenorhabditis elegans)
Gene information (ID: 998)
- Symbol
- vhl-1
- Name
- von Hippel-Lindau tumor suppressor homolog
- Organism
- Caenorhabditis elegans (AnAge)
Potential relevance to longevity and/or ageing
- Observations
- Loss of VHL-1 significantly increased average lifespan (by 30%) and enhanced resistance to polyglutamine and amyloid beta toxicity, no change in MLS
- % change in avg or median lifespan
- Average lifespan is 30% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Observations
- Loss of vhl-1 significantly increased lifespan and resulted in accelerated basal signaling of the p38 mitogen-activated protein kinase PMK-3.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
Homologs in other organisms
No homologs found
External links
- WormBase
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- Ensembl
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- Entrez Gene
- View on Entrez Gene database (181321)
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar