- Symbol
- vang-1
- Name
- Protein VANG-1
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Vang-1 mutations as well as RNAi depletion result in an increased mean lifespan in a DAF-16 dependent manner. The longevity phenotype is accompanied by enhanced resistance to thermal- and oxidative stress and decreased lipofuscin accumulation. Mutants also have a smaller brood size, decreased ovulation rate and prolonged reproductive span.
- % change in avg or median lifespan
- Average lifespan is up to 40% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference and/or mutations
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge microarray genes
- A homolog of this gene for Homo sapiens is present as VANGL2
- Danio rerio
- vangl1
- Danio rerio
- vangl2
- Drosophila melanogaster
- Vang
- Homo sapiens
- VANGL1
- Homo sapiens
- VANGL2
- Mus musculus
- Vangl2
- Mus musculus
- Vangl1
- Rattus norvegicus
- Vangl1
- Rattus norvegicus
- Vangl2
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (180579)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for vang-1 (Caenorhabditis elegans)