- Symbol
- unc-36
- Name
- unc-36
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- Downregulation of unc36-1 in worms extended lifespan by 34% at 25 degrees celcius but not at 15 degrees celcius. Functional decline was delayed in the long-lived worms. However, unc-36 deletion mutants had impaired development resulting in small adult body size and shortened lifespan, suggesting that unc-36 is required maternally or during early life for normal development.
- % change in avg or median lifespan
- Mean lifespan is 34% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Danio rerio
- cacna2d3
- Danio rerio
- cacna2d4b
- Danio rerio
- cacna2d4a
- Danio rerio
- cacna2d4a
- Drosophila melanogaster
- CG4587
- Drosophila melanogaster
- stj
- Drosophila melanogaster
- CG42817
- Homo sapiens
- CACNA2D3
- Homo sapiens
- CACNA2D4
- Mus musculus
- Cacna2d3
- Mus musculus
- Cacna2d4
- Rattus norvegicus
- Cacna2d3
- Rattus norvegicus
- Cacna2d4
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (176155)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for unc-36 (Caenorhabditis elegans)