Caenorhabditis elegansGenAge entry for unc-26 (Caenorhabditis elegans)

Gene information (ID: 703)

Symbol
unc-26
Name
UNCoordinated
Organism
Caenorhabditis elegans (AnAge)
Known functions and activities
Encodes synaptojanin, a polyphosphoinositide phosphatase

Potential relevance to longevity and/or ageing

Observations
Mutations in unc-26 extend lifespan by 30-50%.
% change in avg or median lifespan
Lifespan is 30-50% higher.
Lifespan Effect
Increase
Genetic Manipulation
Mutation
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as INP53
    • A homolog of this gene for Saccharomyces cerevisiae is present as INP51

    Homologs in other organisms

    Danio rerio
    synj1
    Drosophila melanogaster
    Synj
    Homo sapiens
    SYNJ2
    Homo sapiens
    SYNJ1
    Mus musculus
    Synj2
    Mus musculus
    Synj1
    Rattus norvegicus
    Synj1
    Rattus norvegicus
    Synj2
    Saccharomyces cerevisiae
    INP52
    Saccharomyces cerevisiae
    INP51
    Saccharomyces cerevisiae
    INP53
    Schizosaccharomyces pombe
    syj1

    External links

    WormBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (178284)
    Homologues
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    UniProt
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    Internet
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