- Symbol
- top-1
- Name
- TOPoisomerase
- Organism
- Caenorhabditis elegans (AnAge)
- Known functions and activities
- DNA topoisomerase I
- Observations
- RNA interference decreased median lifespan by 19% in wild type animals and 42% in daf-2 mutants.
- % change in avg or median lifespan
- Median lifespan is 19% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as TOP1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as TOP1
- CellAge
- A homolog of this gene for Homo sapiens is present as TOP1
- Danio rerio
- top1mt
- Danio rerio
- zgc:173742
- Danio rerio
- top1l
- Danio rerio
- top1mt
- Danio rerio
- top1
- Drosophila melanogaster
- Top1
- Homo sapiens
- TOP1
- Homo sapiens
- TOP1MT
- Mus musculus
- Top1
- Mus musculus
- Top1mt
- Rattus norvegicus
- Top1
- Rattus norvegicus
- Top1mt
- Rattus norvegicus
- Top1
- Saccharomyces cerevisiae
- TOP1
- Schizosaccharomyces pombe
- top1
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (266847)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for top-1 (Caenorhabditis elegans)