- Symbol
- tdp-1
- Name
- Protein TDP-1
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- TDP-1 loss of function mutants display reduced proteotoxicity in worm models and an extended lifespan, which is DAF-16 dependent but not HSF-1 dependent. The increase in lifespan is also accompanied by a reduction in fertility, slower growth and locomotor deficits.
- % change in max lifespan
- Maximum lifespan is aproximately 20% higher.
- % change in avg or median lifespan
- Average lifespan is aproximately 20% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Loss of function mutation
- Longevity Category
- Anti-Longevity
- Primary reference
-
- Drosophila melanogaster
- CG7804
- Drosophila melanogaster
- TBPH
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (174436)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for tdp-1 (Caenorhabditis elegans)